Symbol
Name
ID

Pax5
paired box 5
MGI:97489

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemias
Disease(s) Associated with PAX5	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemias
acute lymphoblastic leukemia

Mouse Phenotypes

immune system phenotype

abnormal lymphopoiesis

abnormal B cell differentiation

abnormal class switch recombination

decreased immature B cell number

abnormal immunoglobulin heavy chain V(D)J recombination

abnormal late pro-B cell

absent late pro-B cells

arrested B cell differentiation

decreased mature B cell number

absent mature B cells

decreased B-1 B cell number

decreased B-1b cell number

absent B-2 B cells

increased B-1 B cell number

decreased B cell number

decreased pre-B cell number

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD8-positive, alpha-beta memory T cell number

increased memory-marker CD4-positive NK T cell number

increased CD4-positive NK T cell number

increased T cell number

increased single-positive T cell number

increased macrophage cell number

increased monocyte cell number

decreased leukocyte cell number

abnormal B cell physiology

decreased IgA level

decreased IgD level

decreased IgG1 level

decreased IgG2a level

decreased IgG2b level

decreased IgG3 level

decreased IgG level

decreased IgM level

decreased immunoglobulin level

abnormal humoral immune response

impaired humoral immune response

Availability

Mouse Genotype

Pax5^m1Btlr/Pax5^m1Btlr

Pax5^m2Btlr/Pax5^m2Btlr

Pax5^m3Btlr/Pax5^m3Btlr

Pax5^m4Btlr/Pax5^m4Btlr

Pax5^M5Btlr/Pax5^M5Btlr

Pax5^tm1Mbu/Pax5^tm1Mbu

Pax5^tm3.1Mbu/Pax5^tm3.1Mbu

Pax5^tm5Mbu/Pax5^tm5Mbu

Pax5^tm6.1Mbu/Pax5^tm6.1Mbu

Pax5^m2Btlr/Pax5⁺

Pax5^m3Btlr/Pax5⁺

Pax5^{tm1b(EUCOMM)Wtsi}/Pax5⁺

Cd19^tm1(cre)Cgn/Cd19⁺
Pax5^tm1Mbu/Pax5^tm3Mbu (conditional)

Pax5^tm1Mbu/Pax5^tm3Mbu
Tg(Mx1-cre)1Cgn/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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